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Pharmacoepidemiology Department

Dernière mise à jour :

The research platform Bordeaux PharmacoEpi (BPE) of the University of Bordeaux — Public Health Department, created in 2002, has been INSERM CIC 1401 certified since 2008. It carries out high scientific level pharmacoepidemiology studies to assess the impact of medications and therapeutic strategies in real-life care situations. BPE assures the independence of its results by working in the respect of the ENCePP code of conduct. It publishes its results, which participate in the establishment of recommendations meant to optimize the benefits and minimize the risks associated with medication.

Head of Department

Dr Cécile Droz-Perroteau

Research Themes:

  • Advanced methodology in pharmacoepidemiology 

  • Assessment of the uses and performances of the medication in real-life care situations

  • Exploitation of the French National Healthcare Data System (SNDS) data, including the use of innovation methods (ex: HDPS) and techniques (ex: unsupervised machine learning methods)

  • Various areas of expertise linked to the CIC’s research themes: onco-pharmacoepidemiology, cardiology, pulmonology, neurosciences, etc.

  • Assessment of the safety and efficacy of vaccines, particularly those against COVID-29, in France and in Europe

  • Drug risk and at-risk population

Academic reputation and attractiveness

  • Certified “Research platform of the University of Bordeaux” since 2019

  • ISO 9001:v2015 certified for its research activities in pharmacoepidemiology

  • Annual organization of the Bordeaux Pharmacoepi Festival

  • Platform integrated in the pharmacoepidemiology network and in the principal academic societies of the field (ENCePP, ISPE, ISoP, ISPOR, EACPT, SFPT, Eu2P, etc.)

  • Participation to the international consortia and network of excellence in pharmacoepidemiology such as SIGMA, VAC4EU, Conception, IMI-EHDEN, OHDSI, AETION, Eu-ADR

Interactions with the socioeconomic and cultural environment

  • Numerous collaborations with institutional and industrial partners

  • National and international interactions with for example ANSM, HAS, HDH, Iresp, CHU, DGOS, DIRC, DRCI, UB Foundation, EMA, FP7 (EU), FRM, GIRCI, etc

Contribution to training

  • DIU PEP (Inter-University Diploma of Pharmacoepidemiology and Pharmacovigilance 

  • DIU FARC-TEC (Training of Clinical Research Assistants and Clinical Research Technicians)

  • Hosting and supervising interns (Master 1, Master 2…)

Main publications in recent years

2024

  • Hurley E, Geisler BP, Lupattelli A, Poblador-Plou B, Lassalle R, Jové J, Bernard MA, Sakr D, Sanfélix-Gimeno G, Sánchez-Saez F, Rodríguez-Bernal CL, Sabaté M, Ballarín E, Aguilera C, Jordan S, Thayer D, Farr I, Ahmed S, Bartolini C, Limoncella G, Paoletti O, Gini R, Maglanoc LA, Dudukina E, Ehrenstein V, Alsina E, Vaz TA, Riera-Arnau J, Sturkenboom MCJM, Nordeng HME. COVID-19 and pregnancy: A European study on pre- and post-infection medication use. Eur J Clin Pharmacol. 2024 Feb 12. DOI:10.1007/s00228-024-03639-z
  • Raethke M, van Hunsel F, Luxi N, Lieber T, Bellitto C, Mulder E, Ciccimarra F, Riefolo F, Thurin NH, Roy D, Morton K, Villalobos F, Batel Marques F, Farcas A, Sonderlichová S, Belitser S, Klungel O, Trifirò G, Sturkenboom MC. Frequency and timing of adverse reactions to COVID-19 vaccines; A multi-country cohort event monitoring study. Vaccine. 2024 Mar 6:S0264-410X(24)00273-1. DOI:10.1016/j.vaccine.2024.03.001
  • Thurin NH, Grelaud A, Grolleau A, Bernard M-A, Bignon E, Blin P, Lassalle R, Droz-Perroteau C. Design and validation of algorithms to identify venous thromboembolism in the French National Healthcare Database. Pharmacoepidemiol Drug Saf.2024;33:e5781.DOI:10.1002/pds.5781
  • Daveluy A, Bryan MC, Miremont-Salamé G, Lassalle R, Lacueille C, Grelaud A, Floccia M, Haramburu F, Lapeyre-Mestre M, Micallef J, Salvo F. Analgesic switching in chronic users of dextropropoxyphene in France. Fundam Clin Pharmacol. 2024 Apr;38(2):389-397. DOI:10.1111/fcp.12962

 

2023

  • Thurin NH, Jové J, Lassalle R, Rouyer M, Lamarque S, Bosco-Levy P, Segalas C, Schneeweiss S, Blin P, Droz-Perroteau C. Strong instrumental variables biased propensity scores in comparative effectiveness research: A case study in oncology. J Clin Epidemiol. 2023 Mar;155:31-38. DOI:10.1016/j.jclinepi.2023.01.002
  • Kasper S, Foch C, Esser R, Lamy FX, Zhang A, Cheng AL, Rouyer M, Brodowicz T, Zielinski C. Overall survival with cetuximab every-2-weeks versus standard once-weekly administration schedule for first-line treatment of RAS wild-type metastatic colorectal cancer in patients with left- and right-sided primary tumour location. Eur J Cancer. 2023 Feb;180:85-88. DOI:10.1016/j.ejca.2022.11.021
  • Gandaglia G, Pellegrino F, Golozar A, De Meulder B, Abbott T, Achtman A, Imran Omar M, Alshammari T, Areia C, Asiimwe A, Beyer K, Bjartell A, Campi R, Cornford P, Falconer T, Feng Q, Gong M, Herrera R, Hughes N, Hulsen T, Kinnaird A, Lai LYH, Maresca G, Mottet N, Oja M, Prinsen P, Reich C, Remmers S, Roobol MJ, Sakalis V, Seager S, Smith EJ, Snijder R, Steinbeisser C, Thurin NH, Hijazy A, van Bochove K, Van den Bergh RCN, Van Hemelrijck M, Willemse PP, Williams AE, Zounemat Kermani N, Evans-Axelsson S, Briganti A, N'Dow J; PIONEER Consortium. Clinical Characterization of Patients Diagnosed with Prostate Cancer and Undergoing Conservative Management: A PIONEER Analysis Based on Big Data. Eur Urol. 2023 Jul 4:S0302-2838(23)02944-5. DOI:10.1016/j.eururo.2023.06.012
  • Sing CW, Lin TC, Bartholomew S, Bell JS, Bennett C, Beyene K, Bosco-Levy P, Bradbury BD, Chan AHY, Chandran M, Cooper C, de Ridder M, Doyon CY, Droz-Perroteau C, Ganesan G, Hartikainen S, Ilomaki J, Jeong HE, Kiel DP, Kubota K, Lai EC, Lange JL, Lewiecki EM, Lin J, Liu J, Maskell J, de Abreu MM, O'Kelly J, Ooba N, Pedersen AB, Prats-Uribe A, Prieto-Alhambra D, Qin SX, Shin JY, Sørensen HT, Tan KB, Thomas T, Tolppanen AM, Verhamme KMC, Wang GH, Watcharathanakij S, Wood SJ, Cheung CL, Wong ICK. Global Epidemiology of Hip Fractures: Secular Trends in Incidence Rate, Post-Fracture Treatment, and All-Cause Mortality. J Bone Miner Res. 2023 Aug;38(8):1064-1075. DOI:10.1002/jbmr.4821

 

2022

  • Bosco-Lévy P, Foch C, Grelaud A, Sabidó M, Lacueille C,Jové J, Boutmy E, Blin P. Incidence and risk of cancer among Multiple Sclerosis patients: a matched population-based cohort study. Eur J Neurol. 2022 Apr;29(4):1091-1099. DOI10.1111/ene.15226
  • Thurin NH, Pajouheshnia R, Roberto G, Dodd C, Hyeraci G, Bartolini C, Paoletti O, Nordeng H, Wallach-Kildemoes H, Ehrenstein V, Dudukina E, MacDonald T, De Paoli G, Loane M, Damase-Michel C, Beau AB, Droz-Perroteau C, Lassalle R, Bergman J, Swart K, Schink T, Cavero-Carbonell C, Barrachina-Bonet L, Gomez-Lumbreras A, Giner-Soriano M, Aragón M, Neville AJ, Puccini A, Pierini A, Ientile V, Trifirò G, Rissmann A, Leinonen MK, Martikainen V, Jordan S, Thayer D, Scanlon I, Georgiou ME, Cunnington M, Swertz M, Sturkenboom M, Gini R. From Inception to ConcePTION: Genesis of a Network to Support Better Monitoring and Communication of Medication Safety During Pregnancy and Breastfeeding. Clin Pharmacol Ther. 2022 Jan;111(1):321-331. DOI10.1002/cpt.2476

Achievements

  • > 20 years of experience dedicated to the research in pharmacoepidemiology

  • More than 30 field research: from 53 to 46 000 patients

  • More than 600 studies on the Data base of the French Health Insurance 

  • More than 85 publications in the last 5 years

  • Since 2010, organization of the annual event: the Bordeaux PharmacoEpi Festival

Contact

cecile.droz%40u-bordeaux.fr

05 57 57 46 75